Intracytoplasmic Sperm Injection (ICSI) in Los Angeles
In ICSI, a single sperm is injected into a harvested egg to artificially fertilize the egg. This technique, offered at the California Center of Reproductive Health’s state-of-the-art embryology laboratory in West Hollywood, has helped numerous couples build their families in the greater Los Angeles area and beyond.
Intracytoplasmic Sperm Injection (ICSI)
Intracytoplasmic sperm injection, or ICSI, is a specialized laboratory technique which allows for the injection of a single sperm (spermatozoa) into an egg in order to achieve fertilization. In standard in vitro fertilization (IVF), between 50,000 and 100,000 sperm are placed in the same dish as a single egg, and sperm are allowed to naturally fertilize the egg. In the event that no abnormalities in the sperm exist, normal fertilization is often confirmed the next morning. However, in cases of male factor infertility where significant abnormalities in the count, motility, and/or shape of the sperm exist, IVF results in very poor fertilization rates, often resulting in no fertilized eggs and thus no embryos for transfer. Since ICSI involves the injection of only a single sperm into each egg, even the most severe of male factor abnormalities can be overcome. Using special micromanipulation tools, a single morphologically normal motile sperm is immobilized, loaded into a fine hollow needle, and carefully injected through the egg shell (zona pellucida), membrane, and into the center (cytoplasm). Fertilization rates with ICSI are generally excellent, on the order of 75-85%.
Various indications have evolved over the years for ICSI. In addition to male factor infertility, ICSI has successfully been employed in cases of unexplained infertility, prior fertilization failure, antisperm antibodies, and in cases where only a small number of eggs are available for fertilization. Numerous clinical trials and studies have illustrated the safety of ICSI.
The California Center for Reproductive Health uses ICSI as an adjunct to many other micromanipulation techniques to optimize a couple’s chances of conceiving.
FAQ
Reproductive endocrinology and Infertility is a sub-specialty of Obstetrics and Gynecology. In addition to managing medical and surgical treatment of disorders of the female reproductive tract, reproductive endocrinologist and infertility (REI) specialists undergo additional years of training to provide fertility treatments using assisted reproductive technology (ART) such as in vitro fertilization.
Reproductive endocrinologists receive board certification by the American Board of Obstetrics and Gynecology in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility.
In general, patients should consider consulting with an REI specialist after one year of trying unsuccessfully to achieve pregnancy. The chance of conceiving every month is around 20%, therefore after a full year of trying approximately 15% of couples will still not have achieved a pregnancy.
However, if a woman is over the age of 35 it would be reasonable to see a fertility specialist earlier, typically after 6 months of trying.
Other candidates to seek earlier treatment are women who have irregular menses, endometriosis, fibroids, polycystic ovary syndrome (PCOS), women who have had 2 or more miscarriages, or problems with the fallopian tubes (prior ectopic pregnancy).
Approximately 1/3 of the time cause for infertility is a female factor, 1/3 of the time a male factor, and the remaining 1/3 a couples’ factor.
At CCRH, we emphasize the importance of establishing a correct diagnosis. Both partners undergo a comprehensive evaluation including a medical history and physical exam.
Furthremore, the woman’s ovarian reserve is assessed with a pelvic ultrasound and a hormonal profile. A hysterosalpingogram (HSG) will confirm fallopian tube patency and the uterine cavity is free of intracavitary lesions. A semen analysis is also obtained to evaluate for concentration, motility, and morphology of the sperm.
Additional work up is then individualized to direct the best possible treatment option for each couple.
In vitro fertilization (IVF) is the process that involves fertilization of an egg outside of a woman’s body.
The process starts with fertility drugs prescribed to help stimulate egg development. In your natural cycle, your body is only able to grow one dominant egg, but with stimulation medication we can recruit multiple eggs to continue to grow. After about 8-10 days of stimulation, the eggs are surgically retrieved and then fertilized with sperm in a specialized laboratory. Fertilized eggs are then cultured under a strictly controlled environment within specialized incubators in the IVF laboratory for 3-5 days while they develop as embryos. Finally, embryos (or an embryo) are transferred into the uterine cavity for implantation.
Before deciding if IVF is the right choice, it’s important to sit down with an REI specialist to discuss available treatment options. For some people, other methods such as fertility drugs, intrauterine insemination (IUI) may be the best first choice treatment. At CCRH, we believe each individual couple is unique and not everyone needs IVF.
While not painful, the fertility medications may some side effects including headaches, hot flashes, mood swings, and bloating. The injection sites may also bruise.
Unfortunately, no. Many people think once they start IVF it’s a matter of time that they will be pregnant and have a baby. But according to national statistics per the Society of Assisted Reproduction (SART), on average 40% of assisted reproduction cycles achieve live births in women under age 35. The chances of success then continue to decrease with advancing age.
At CCRH, we employ only evidence-based interventions to ensure patient safety and optimal outcome. While we cannot guarantee a baby, we guarantee that you will receive the best, most advanced, personalized care to help you maximize your chance of a baby.
The average IVF success rate (success measured in live birth rate) using one’s own eggs begins to drop around age 35 and then rapidly after age 40. This is due to the decline in egg quantity and egg quality as a woman ages.
Our clinic’s success rate consistently beats the national average year after year.
Individual insurance plans often do not have any coverage for infertility treatments. If you have a group plan, you can call members services to see if they have coverage for infertility (including consultation/workup and IVF).
After your consultation with our REI specialist, one of our dedicated account managers with sit with you to go over the cost of treatment.